Table 3.
Mean subcortical volume change in ml per year
| Controls | Premanifest HD gene carriers | ||
|---|---|---|---|
| Non-converters | Converters | ||
| Accumbens | - 0.018 (0.027) | - 0.035 (0.046) | - 0.020 (0.014) |
| Pallidum | 0.006 (0.041) | - 0.054 (0.056) | - 0.049 (0.043)* |
| Amygdala | - 0.0012 (0.107) | 0.031 (0.109) | - 0.020 (0.063) |
| Putamen | - 0.022 (0.082) | - 0.165 (0.128) | - 0.123 (0.066) |
| Caudate nucleus | - 0.023 (0.048) | - 0.086 (0.079)* | - 0.125 (0.052)* |
| Thalamus | - 0.067 (0.099) | - 0.015 (0.090) | - 0.106 (0.070) |
| Hippocampus | - 0.010 (0.123) | 0.029 (0.041) | - 0.066 (0.084) |
Mean individual linear regression coefficients (standard deviation) indicate the change (increase or decrease) in volume for each subcortical structure for every additional year. In the statistical regression analyses, the ratio between subcortical volume and total intracranial volume at each measurement was used to account for an individuals’ brain volume. A one-way analysis of covariance (ANCOVA) for group differences was performed with age and gender as covariates. Post-hoc analyses were adjusted for multiple comparisons using a Bonferonni correction
*Significantly different compared to controls, p < 0.05