Table 1.
Baseline Characteristics by Treatment Group
| Characteristic | Galantamine + CBT4CBT | Galantamine + TAUb | Placebo + CBT4CBT | Placebo + TAU | F or X2 | p-value |
|---|---|---|---|---|---|---|
| (n= 28) | (n=27) | (n=38) | (n=27) | |||
| Female, No. (%) | 12 (43%) | 11 (41) | 10 (26) | 7 (26) | 3.32 | .35 |
| Race and ethnicity, No. (%) | ||||||
| Caucasian | 12 (42) | 15 (56) | 19 (50) | 16 (60) | 5.34 | .80 |
| African-American | 7 (25) | 6 (22) | 9 (24) | 3 (11) | ||
| Hispanic | 9 (32) | 6 (22) | 9 (24) | 8 (30) | ||
| Multiracial/Other | 0 | 0 | 1 (3) | 0 | ||
| Completed high school, No. (%) | 17 61) | 19 (70) | 29 (77) | 21 (78) | 2.58 | .46 |
| Unemployed, No. (%) | 20 (71) | 21 (78) | 27 (71) | 19 (70) | 0.50 | .92 |
| On public assistance, No. (%) | 23 (83) | 21 (78) | 23 (61) | 18 (67) | 4.55 | .21 |
| Major depression -lifetimea, No. (%) | 1 (4) | 3 (11) | 2 (5) | 4 (15) | 3.06 | .38 |
| Anxiety disorder -lifetime, No. (%) | 3 (11) | 5 (19) | 2 (5) | 5 (19) | 3.69 | .30 |
| Antisocial personality dis., No. (%) | 3 (11) | 3 (11) | 5 (13) | 5 (19) | 0.91 | .82 |
| Alcohol use dis.-lifetime, No. (%) | 15 (54) | 14 (52) | 21 (55) | 16 (59) | 0.33 | .95 |
| Age, mean (SD) | 38.0 (8.7) | 38.7 (10.8) | 39.8 (9.0) | 36.3 (9.4) | 0.75 | .52 |
| Days marijuana use, past 28, mean (SD) | 4.9 (8.9) | 3.3 (7.8) | 2.0 (5.5) | 3.3 (7.4) | 0.80 | .50 |
| Days cocaine use, past 28, mean (SD) | 17.2 (8.3) | 12.4 (8.1) | 13.6 (8.5) | 13.4 (7.9) | 1.80 | .15 |
| Days cigarette use, past 28, mean (SD) | 27.1 (4.9) | 25.4 (7.8) | 27.3 (4.5) | 25.3 (7.9) | 0.81 | .49 |
| Days alcohol use, past 28, mean (SD) | 2.9 (5.3) | 4.6 (7.8) | 1.7 (4.9) | 1.7 (3.1) | 1.79 | .15 |
| Days opiate use, past 28, mean (SD) | 1.6 (2.5) | 3.3 (4.4) | 4.3 (7.9) | 1.5 (2.6) | 2.15 | .10 |
| Days benzodiazepine use, past 28, mean (SD) | 0.5 (1.9) | 0.3 (0.7) | 0.3 (0.8) | 0.3 (1.0) | 0.20 | .90 |
| Age of first cocaine use, mean (SD) | 18.1 (3.5) | 20.2 (6.1) | 20.6 (6.6) | 20.2 (5.0) | 1.27 | .29 |
| Years of regular cocaine use, mean (SD) | 10.2 (8.7) | 12.6 (10.3) | 8.5 (7.1) | 8.5 (8.1) | 1.53 | .21 |
| Lifetime number of arrests, mean (SD) | 6.6 (7.3) | 7.2 (10.9) | 8.9 (14.7) | 5.8 (6.6) | 0.50 | .69 |
| Number of prior outpt drug treatments, mean (SD) | 3.5 (4.6) | 2.3 (2.7) | 2.4 (2.6) | 2.5 (2.2) | 0.97 | .41 |
| Number of prior inpt drug treatments, mean (SD) | 2.6 (2.5) | 3.7 (6.8) | 3.4 (5.7) | 2.4 (3.9) | 0.46 | .71 |
| Estimated IQ from Shipley, mean (SD) | 98.4 (11.7) | 101.6 (12.2) | 101.4 (11.4) | 100.5 (11.9) | 0.45 | .72 |
| Methadone dose, mg/day, mean (SD) | 77.3 (35.7) | 65.3 (25.3) | 72.4 (26.4) | 65.3 (25.6) | 1.15 | .33 |
Abbreviations: GAL=galantamine, PLA=placebo, CBT4CBT=computerized cognitive behavioral therapy, TAU=standard methadone treatment as usual
a
All psychiatric diagnoses made from SCID interviews for DSM-IV-R