. 2018 Mar 15;24:1540–1546. doi: 10.12659/MSM.908172

Table 2.

Comparison of study parameters between two groups. Blood samples were taken at four different time points.

Variable	All patients n=70	Group 1 (N-acetylcysteine) n=35	Group 2 (Controls) n=35	P values^*
Creatinin, mg/dl
Preop	0.97±0.23	0.94±0.20	1.01±0.26	^a0.2412
After bypass	1.00±0.24	1.00±0.23	0.99±0.25	^a0.8598
At the 24^th hour after surgery	1.11±0.29	1.09±0.24	1.13±0.33	^a0.5708
At the 48^th hour after surgery	1.17±0,32	1.08±0.31	1.25±0,30	^a0.0237

BUN, mg/dl
Preop	18±4.9	18±5.0	18±4.6	^a0.4479
After bypass	18±7.0	17±4.6	19±5.7	^a0.2019
At the 24^th hour after surgery	22±8.0	19±4.4	23±6.2	^a0.0010
At the 48^th hour after surgery	22±9.0	20±5.4	23±6.9	^a0.0287

AST, IU/L
Preop	25±12	26±13	23±10	^a0.3360
After bypass	35±20	36±16	34±23	^a0.5599
At the 24^th hour after surgery	45±31	41±17	48±41	^b0.8555
At the 48^th hour after surgery	48±35	42±22	55±44	^a0.1297

ALT, IU/L
Preop	24±14	24±16	25±11	^a0.9520
After bypass	26±17	25±18	28±16	^b0.1923
At the 24^th hour after surgery	32±23	30±23	33±23	^b0.3384
At the 48^th hour after surgery	29±20	30±25	29±15	^b0. 6217

ALP, IU/L
Preop	78±28	75±31	82±24	^a0.3525
After bypass	72±23	69±26	75±19	^a0.2440
At the 24^th hour after surgery	78±29	78±35	78±23	^a0.9612
At the 48^th hour after surgery	71±25	69±20	74±29	^a0.3422

CK-MB, IU/L
Preop	17±8	18±8	17±8	^b0.6510
After bypass	37±28	37±24	36±32	^a0.8774
At the 24^th hour after surgery	53±61	52±28	54±82	^b0.0954
At the 48^th hour after surgery	40±56	32±19	48±77	^b0.2131

TnI, ng/ml
Preop	0.33±0.91	0.38±1.20	0.28±0.47	^b0.4557
After bypass	3.76±7.09	3.58±5.15	3.93±8.68	^b0.6427
At the 24th hour after surgery	6.85±9.43	5.05±5.80	8.64±11.84	^b0.6724
At the 48th hour after surgery	8.87±10.90	7.15±7.06	10.59±13.61	^a0.1887

NH3, mcg/dl
Preop	39.4±10.5	37.4±9.1	41.4±11.5	^a0.1146
After bypass	42.4±13.3	37.8±10.3	47.0±14.5	^a0.0031
At the 24^th hour after surgery	47.2±17.2	39.0±8.8	55.4±19.6	^a<0.0001
At the 48^th hour after surgery	46.6±16.7	40.1±8.4	53.2±20.2	^a0.0007

Lactate, mmol/L
Preop	1.0±0.4	0.9±0.3	1.0±0.4	^a0.2655
After bypass	1.0±0.3	0.9±0.3	1.0±0.4	^a0.0828
At the 24^th hour after surgery	1.7±0.9	1.4±0.5	2.1±1.2	^a0.0018
At the 48^th hour after surgery	1.5±1.1	1.2±0.5	1.8±1.4	^b0.0083

Comparison was based on

unpaired t test;

Mann-Whitney Test.