Table 3.

Kidney and liver parameters (mean ± SEM) after 6 weeks of RVD (before treatment) and then 4 weeks after administration of ELP-VEGF intravenous injection (efficacy studies, single dose, 1 mg/kg).

Parameter	Plasma-6 weeks	Plasma-10 weeks	Normal Range	P value
BUN (mg/dL)	8.3±0.7	5.0±0.5	8–24 mg/dL	0.03*
Creatinine (mg/dL)	1.4±0.1	1.5±0.08	1–3 mg/dL	0.64
BUN/Creatinine ratio	6.1±0.5	3.4±0.1		0.04*
ALT (U/L)	43.7±6.5	50.7±3.7	31–58 U/L	0.91
AST (U/L)	38.0±2.2	32.3±3.3	32–84 U/L	0.16
GGT (U/L)	32.3±4.3	29.0±2.3	10–60 U/L	0.70
LDH (U/L)	488.7±19.6	487.3±63.9	380–630 U/L	0.91

^*p<0.05 10 vs. 6 weeks (pre-treatment)

BUN: blood urea nitrogen

ALT: alanine aminotransferase

AST: aspartate aminotransferase

GGT: gamma-glutamyl transferase

LDH: lactate dehydrogenase