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. Author manuscript; available in PMC: 2019 Mar 30.
Published in final edited form as: J Mol Biol. 2018 Feb 6;430(7):1024–1050. doi: 10.1016/j.jmb.2018.01.021

Figure 1. A UBE3A-centered protein interaction network.

Figure 1

This network displays interactors of UBE3A found by AP-MS or Y2H as well as interactors of its associated proteins. All links shown in the network are supported by at least two different sources (see Methods). Highlighted are a few key protein complexes of which all apart from the ribosome are significantly enriched in the systematically built network of UBE3A using only QBCHL as source of interactions (see Figure S2).