Fig. 3.

Blood concentrations of E2 (a) and BPA (b) in rats upon oral administration. Symbols represent the average blood concentrations from in vivo studies reported in the literature. Lines represent blood concentrations predicted by the PBK model. Dose levels are as follows: a E2, 0.02 mg/kg bw (triangles, dotted line) and 0.08 mg/kg bw (squares, dashed line) (Bawarshi-Nassar et al. 1989); b BPA, 10 mg/kg bw (squares, straight line) and 100 mg/kg bw (triangles, dashed line) (Pottenger et al. 2000)