Fig. 4.
Normalized sensitivity coefficients of PBK model parameters for the predicted C max of parent compound in blood after oral administration of 0.02 mg/kg bw E2 (white bars) or 10 mg/kg bw BPA (dark grey bars). All model parameters with normalized sensitivity coefficients with an absolute value higher than 0.1 are shown. VLc = fraction of liver tissue, QFc = fraction of blood flow to fat, QLc = fraction of blood flow to liver, P app, Caco-2 = P app valued derived from Caco-2 transport studies, Vin = intestine volume for intestinal sub-compartment, SAin = intestinal surface area for intestinal sub-compartment, kin = transfer rate within intestinal sub-compartments, PS = slowly perfused tissue/blood partition coefficient, CLint = experimental hepatic clearance of parent compound, S9P = S9 protein concentration in rat liver