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. 2017 Dec 12;92(3):1075–1088. doi: 10.1007/s00204-017-2140-5

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 6 — Predicted in vivo dose–response data in rats compared with in vivo data on uterotrophic growth upon exposure to E2 (a) and BPA (b). The predicted responses are shown as a percentage of maximum response induced by the chemical. Symbols represent the response derived from different in vitro assays, MCF-7/BOS proliferation assay (triangles, dotted line), U2OS ER-CALUX assay (squares, dash-dotted line), YES assay (circles, dashed line), or the absolute uterus weight increase of rats in the in vivo uterotrophic assay. For E2 (a), the in vivo data are from Odum et al. (1997) (diamonds, straight line). For BPA (b, d), in vivo data are from Tinwell and Ashby (2004) (diamonds, straight line) and from Kanno et al. (2003) (cross, straight line)