Fig. 7.

Comparison of the BMD₁₀ values (including BMDL₁₀ and BMDU₁₀ values) from predicted dose–response and in vivo dose-response data of E2 (empty box) and BPA (dotted box). Predicted dose–response data were obtained by PBK modelling-based reverse dosimetry of in vitro data from the YES assay and in vivo data were obtained from uterotrophic assay studies reported in the literature (E2: (Odum et al. 1997), BPA: (Kanno et al. 2003) and (Tinwell and Ashby 2004)). BMD analysis was performed using the BMR as a 10% response change as compared to the control using PROAST. The results are presented as the range between the BMDL₁₀ and BMDU₁₀ values reported, giving the BMD₁₀ values as straight line in between