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. 2017 Dec 12;92(3):1075–1088. doi: 10.1007/s00204-017-2140-5

Table 1.

In vitro clearance (CLint) for E2 and BPA using male Sprague–Dawley rat liver S9 fraction incubated with individual co-factors

Compound Co-factor CLint (µL/min/mg protein)
E2 NADPH 154.7 ± 26.7
UDPGA 23.3 ± 0.9
PAPS 4.4 ± 1.6
Acetyl CoA *
SUM 182.4 ± 26.8
BPA NADPH 60.0 ± 4.8
UDPGA 339.7 ± 7.8
PAPS 3.4 ± 2.1
Acetyl CoA *
SUM 403.1 ± 9.4

* No CLint value can be derived from the incubation