Table 5.

Overview of in vivo uterotrophic assay data from literature used to evaluate predicted in vivo dose-dependent estrogenic effects based on PBK modelling-based reverse dosimetry of in vitro estrogenicity data

Compound	Species (strain)	Dose (mg/kg bw)	Exposure route	References
E2	Rat (AP)	0, 0.01, 0.02, 0.04, 0.1, 0.2, 0.4	Oral gavage	Odum et al. (1997)
BPA	Rat (Sprague–Dawley)	0, 60, 200, 375, 600, 1000	Oral gavage	Kanno et al. (2003)
BPA	Rat (AP)	0, 10, 100, 300, 600, 800	Oral gavage	Tinwell and Ashby (2004)