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Metabolism of the precursors Tam, DM-Tam and DDM-Tam to Met E and 4OH-Tam, Endox, Norendox and both isomers of Met E to Tam-Bis. Pooled human liver microsomes (HLM) were incubated with 50 µM of Tam, DM-Tam and DDM-Tam to analyze formation to (Z)- (a) and (E)-Met E (b) or 50 µM of 4OH-Tam, Endox and Norendox (c), as well as both isomers of Met E (d) to analyze the metabolism to Tam-Bis. Data are presented as mean ± SD
