Table 3.
Mutation types and mutant allele fraction (MAF) (%) changes.
| #1 | #5 | ||||||
|---|---|---|---|---|---|---|---|
| Before osimertinib | After osimertinib | Before osimertinib | After osimertinib | ||||
| Mutation | Rate | Mutation | Rates | Mutation | Rates | Mutation | Rates |
| L858R | 42.9 | L858R | 63.2 | 19 del | 9.6 | 19 del | 2.1 |
| IL7R | 19.1 | IL7R | 31.5 | T790M | 1.1 | PIK3CA | 1.8 |
| T790M | 5.7 | TENM3 | 27.1 | TP53 | 7.11 | TP53 | 1.7 |
| CCND3 | 5.8 | CCND3 | 14.3 | RNASEL | 1.2 | ||
| WSCD2 | 5.1 | ROS1 (6737 G>A) | 2.9 | TET2 | 0.8 | ||
| FGR3A | 4.1 | FGFR3 | 1.9 | MAP3K1 | 0.8 | ||
| XPC | 1.5 | ||||||
| ATM | 1.5 | ||||||
| FAM135B | 1.2 | ||||||
| PALB2 | 1.1 | ||||||
| MLL | 1 | ||||||
| ROS1 (1611A>G) | 1 | ||||||
| CDKN2A | 0.2 | ||||||
| Altered copy | |||||||
| CDKN2B DEL | 0.3 | ||||||
| CDKN2A DEL | 0.2 | ||||||