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The distributions of SIRPB1 and TMEM91 CNVs in AITD patients and controls.
| Gene/CNV | Case, n (%) N = 158 |
Control, n (%) N = 181 |
p value |
|---|---|---|---|
| SIRPB1 | |||
| Normal | 138 (87.34) | 174 (96.13) | |
| Loss | 9 (5.70) | 6 (3.32) | 0.288 |
| Gain | 11 (6.96) | 1 (0.55) | 0.001∗ |
| TMEM91 | |||
| Normal | 148 (93.67) | 176 (97.24) | |
| Loss | 9 (5.70) | 4 (2.21) | 0.095 |
| Gain | 1 (0.63) | 1 (0.55) | 1.000 |
∗The frequency of CNV gain for SIRPB1 gene in the case group was significantly higher than that in the control group.
