Table 2.
The summary of pharmacokinetic parameters of Gd-EOB-DTPA.
| Control (n = 16) |
70% hepatectomy (n = 14) |
90% hepatectomy (n = 20) |
|
|---|---|---|---|
| AUClast (μmol·min/L) | 2501.0 ± 922.6 | 3956.6 ± 1067.2 | 9234.5 ± 3891.5 |
| AUCinf (μmol·min/L) | 2659.6 ± 1099.2 | 4292.3 ± 1281.8 | 14199.8 ± 10949.0 |
| AUCextrapolated (%) | 5.1 ± 3.2 | 7.1 ± 3.3 | 24.7 ± 15.2 |
| AUCinf/dose (μmol·min/L/μmol) | 90.1 ± 43.1 | 160.6 ± 49.0 | 545.0 ± 417.5 |
| C max (μmol/L) | 238.1 ± 62.4 | 264.1 ± 58.2 | 334.9 ± 65.6 |
| C max/Dose (μmol/L/μmol) | 8.0 ± 2.6 | 9.9 ± 2.3 | 12.9 ± 2.9 |
| CL (ml/min) | 12.7 ± 4.1 | 6.8 ± 2.3 | 2.7 ± 1.5 |
| V ss (mL) | 269.7 ± 70.1 | 189.1 ± 36.0 | 142.1 ± 39.3 |
| V z (mL) | 487.7 ± 157.0 | 254.9 ± 62.1 | 160.6 ± 55.2 |
| t 1/2β (min) | 27.3 ± 5.9 | 27.0 ± 5.3 | 52.6 ± 30.2 |
| t 1/2,eff (min) | 15.6 ± 4.5 | 20.3 ± 4.5 | 48.1 ± 30.1 |
Data are presented as means ± standard deviation. AUClast: area under the serum concentration-time curve from time zero to time of last measurable concentration; AUCinf: AUC from time zero to time extrapolated to infinite time; AUCextrapolated (%): AUC from time of last measurable concentration extrapolated time to infinite time/AUCinf; Cmax: measured peak plasma concentration; CL: clearance; Vss: steady-state volume of distribution; Vz: terminal phase volume of distribution; t1/2β: terminal half-life; t1/2,eff: effective half-life.