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. 2018 Mar 25;14(3):e7974. doi: 10.15252/msb.20177974

Figure 3. An important fraction of hotspot mutations has a role in inactivating tumor suppressors.

Figure 3

  1. A number of hotspot mutations are associated with tumor suppressors. Among these are RBL2 and KLF5 proteins that are not in the Cancer Gene Census, but are homologs of cancer drivers. Hotspot mutations within these proteins are shown as dark red circles, while missense and highly deleterious mutations are depicted as blue and gray circles, respectively. The encoded Pfam domains are shown as colored boxes.
  2. Almost a third (i.e., 32%) of the genes with better‐annotated, more common hotspot mutations (observed in at least ten patients) are tumor suppressors. Another prominent category is genes with apparently activating mutations that affect binding properties of oncogenes (51% of the total 53 genes).