Table 1.
Significant gene hits with mutation clusters at the interaction interfaces that are currently not in the Cancer Gene Census
| Gene name | P‐value |
|---|---|
| CARM1 | 3.43E‐09 |
| C5 | 6.05E‐07 |
| METTL14 | 1.30E‐06 |
| CUL1 | 2.83E‐06 |
| ABCD1 | 1.67E‐05 |
| SCN2A | 1.82E‐4 |
| IL1RAP | 2.07E‐4 |
| MAP1LC3A | 3.66E‐4 |
| CNOT1 | 3.66E‐4 |
| ITGAX | 0.001 |
| CUL4B | 0.001 |
| UCHL1 | 0.001 |
| SUPT5H | 0.002 |
| BMP2 | 0.002 |
| CSF2RB | 0.002 |
| GNB1 | 0.002 |
| LRRC4C | 0.002 |
| C6 | 0.003 |
| WDR5 | 0.003 |
| POLR1A | 0.003 |
| ILK | 0.004 |
| RXRA | 0.004 |
| FLT1 | 0.005 |
| UBA3 | 0.005 |
| IL6 | 0.006 |
| PRKAG3 | 0.007 |
| TLR4 | 0.009 |
| MCM6 | 0.009 |
| TNPO1 | 0.010 |
| CYFIP1 | 0.011 |
| ACTB | 0.012 |
| CHRNB2 | 0.013 |
| MPO | 0.013 |
| MCM7 | 0.013 |
| SERPINA10 | 0.014 |
| EIF5A | 0.014 |
| KPNA1 | 0.014 |
| CDC7 | 0.015 |
| ITGA2B | 0.019 |
| F10 | 0.019 |
| IRF7 | 0.019 |
| RPA1 | 0.019 |
| CHP2 | 0.020 |
| RAMP2 | 0.024 |
| COL4A2 | 0.024 |
| GNG2 | 0.025 |
| CAB39 | 0.026 |
| C3 | 0.028 |
| CFB | 0.030 |
| TAF1 | 0.031 |
| KDM1B | 0.034 |
| TRAF2 | 0.034 |
| SCAF8 | 0.037 |
| MAPK8 | 0.037 |
| IL21 | 0.037 |
| XRCC5 | 0.045 |
| TTC7B | 0.046 |
| PSMB3 | 0.046 |