Table 2.
Estimated Difference (per 1,000 Person Years) in Joint Replacement Rates Following Approval of TNFi in England and Wales
| Outcome | Without intervention 1 | With intervention 1 | Absolute Difference 2 | ||
|---|---|---|---|---|---|
| estimate | lower 95% C.I. | upper 95% C.I. | |||
| Total Hip Replacement | 5.63 | 6.57 | 0.95 | -2.66 | 4.56 |
| Total Knee Replacement | 12.92 | 8.51 | -4.41 | -6.88 | -1.94 |
1
Post-NICE TA 36 midpoint estimate (June 2006)
2
Calculated by comparing estimated values for midpoint of post-intervention period to counterfactual values for the same time point (i.e. post-intervention midpoint values estimated based solely on extrapolation of pre-intervention level and/or trend). Estimated from parsimonious models