Table 4.
Putative Functions of the Most Frequently Identified Nonhomologous Domains in Hemerythrin‐like Proteins
|
Pfam ID (Accession) |
Domain description | Putative functiona | Amino acid motif of the associated hemerythrin‐like domain |
|---|---|---|---|
| TadZ_N (PF16968) | N‐terminal domain of the pilus assembly protein TadZ | Signal‐transduction‐response receiver | H‐HxxxE‐HxxxH‐HxxxxD |
| HPTransfase (PF10090) | Histidine phosphotransferase | Signal transduction | H‐HxxxE‐HxxxH‐HxxxxD |
| MEKHLA (PF08670) | Shares similarity with the PAS domain | Signal sensor | H‐HxxxE‐HxxxH‐HxxxxD |
| GGDEF (PF00990) | GGDEF domain | Diguanylate cyclase, signal transduction | H‐HxxxE‐HxxxH‐HxxxxD |
| MCPsignal (PF00015) | Methyl‐accepting chemotaxis protein (MCP) signaling domain | Signal transduction | H‐HxxxE‐HxxxH‐HxxxxD |
| TarH (PF02203) | Tar (taxis towards aspartate and maltose, away from nickel and cobalt) ligand binding domain homolog | Signal transduction, chemotaxis | H‐HxxxE‐HxxxH‐HxxxxD |
| HAMP (PF00672) | HAMP domain (present in Histidine kinases, Adenyl cyclases, Methyl‐accepting proteins and Phosphatases) | Signal transduction | H‐HxxxE‐HxxxH‐HxxxxD |
| PDEase_II (PF02112) | cAMP phosphodiesterases class‐II | cAMP catabolic process | H‐HxxxE‐HxxxH‐HxxxxD |
| sCache_2 (PF17200) | Single cache (CAlcium channels and CHEmotaxis receptors) domain 2 | Signal transduction, small‐molecule recognition | H‐HxxxE‐HxxxH‐HxxxxD |
| Popeye (PF04831) | Member of the conserved barrel domain of the cupin superfamily | Unknown | H‐HxxxE‐HxxxH‐HxxxxD |
| SprT‐like (PF10263) | Domain of unknown function | Unknown | H‐HxxxE‐HxxxH‐HxxxxD |
| DUF1858 (PF08984) | Domain of unknown function | Unknown | H‐HxxxE‐HxxxH‐HxxxxD |
| Prok‐RING_2 (PF14445) | Prokaryotic RING finger family 2 | Associated with components of the ubiquitin‐based signaling and degradation system | H‐HxxxE‐H‐HxxxE |
| zf‐CHY (PF05495) | Zinc fingers motif | Unknown | H‐HxxxE‐H‐HxxxE |
| zf‐rbx1 (PF12678) | Zinc fingers motif | Unknown | H‐HxxxE‐H‐HxxxE |
| zinc_ribbon_6 (PF14599) | Zinc fingers motif | Unknown | H‐HxxxE‐H‐HxxxE |
| TAT_signal (PF10518) | TAT (twin‐arginine translocation) pathway signal sequence. Transport of folded proteins across energy‐transducing membranes | Transport across membranes | H‐HxxxE‐H‐HxxxE |
| E1‐E2_ATPase (PF00122) | Proton‐ATPase | Transport across membranes | H‐HxxxE‐H‐HxxxE |
| GST_N_3 (PF13417) | Glutathione S‐transferase, N‐terminal domain | Glutathione metabolism. | H‐HxxxE‐H‐HxxxE |
| Pyrid_ox_like (PF16242) | Pyridoxamine 5'‐phosphate oxidase like | Putative a defense mechanism against oxidative stress | H‐HxxxE‐H‐HxxxE |
| Hydrolase (PF00702) | Haloacid dehalogenase‐like hydrolase | Hydrolase activity | H‐HxxxE‐H‐HxxxE |
| UMPH‐1 (PF05822) | Pyrimidine 5'‐nucleotidase | Hydrolase activity | H‐HxxxE‐H‐HxxxE |
| Bac_luciferase (PF00296) | Luciferase‐like flavin monooxygenase (LLM) domain | Oxygenase activity | H‐HxxxE‐H‐HxxxE |
| MetRS‐N (PF09635) | N‐terminal domain of methionyl‐tRNA synthetase which adopts a glutathione S‐transferase (GST)‐like fold | Unknown | H‐HxxxE‐H‐HxxxE |
| ScdA_N (PF04405) | Repair of iron centers domain | Unknown | H‐HxxxE‐H‐HxxxE |
| DUF2249 (PF10006) | Domain of unknown function | Unknown | H‐HxxxE‐H‐HxxxE |
| F420H2_quin_red (PF04075) | F420H(2)‐dependent quinone (Fqo) reductase | Unknown | H‐HxxxE‐H‐HxxxE |
| DUF2481 (PF10654) | Domain of unknown function | Unknown | H‐HxxxE‐H‐HxxxE |
| DUF1858 (PF08984) | Domain of unknown function | Unknown | H‐HxxxE‐H‐HxxxE |
| PAS_10 (PF13596) | PAS: Per‐Arnt‐Sim domain (present in period circadian protein, aryl hydrocarbon receptor nuclear translocator protein, single‐minded protein) | Involved in oxidative stress protection | Not conserved |
| DUF438 (PF04282) | Domain of unknown function | Unknown | Not conserved |
| F‐box_4 (PF15966) | F‐box protein. | Protein‐protein interactions | H‐HExxE‐H‐HxxxE |
| LRR_9 (PF14580) | Leucine‐rich repeat. | Protein‐protein interactions | H‐HExxE‐H‐HxxxE |
a
Information about putative domain functions was gathered from InterPro.36