. 2018 Jan 28;32(2):712–721. doi: 10.1111/jvim.14853

Table 2.

End‐tidal isoflurane (ET_ISO) and hemodynamic parameters of six anesthetized dogs (mean ± SD) that did not undergo intervention (Control treatment) or that underwent hemorrhage and randomly received volume replacement with lactated Ringer's solution (LRS treatment) or with 6% tetrastarch (TS treatment) at a ratio of 3 : 1 or 1 : 1 the volume of shed blood, respectively. Variables recorded before hemorrhage (BL), immediately after blood withdrawal over 30 minutes (BW), immediately after volume replacement over 30 minutes (VR), and during 4 hour after VR

Variable	Treatment	BL	BW	VR	Time after VR (hour)
Variable	Treatment	BL	BW	VR	0.5	1	2	3	4
ET_ISO (%)	Control	1.35 ± 0.51	1.37 ± 0.53	1.32 ± 0.48^ab	1.33 ± 0.49	1.32 ± 0.45	1.43 ± 0.34	1.48 ± 0.34	1.37 ± 0.43
	LRS	1.37 ± 0.33	1.27 ± 0.21	1.12 ± 0.29^a	1.20 ± 0.06	1.33 ± 0.23	1.38 ± 0.31	1.52 ± 0.34	1.42 ± 0.29
	TS	1.53 ± 0.36	1.42 ± 0.37	1.35 ± 0.33^b	1.40 ± 0.32	1.42 ± 0.25	1.48 ± 0.31	1.48 ± 0.35	1.48 ± 0.33
HR (beats/min)	Control	96 ± 27	99 ± 29^a	97 ± 28	97 ± 28^a	93 ± 24^a	96 ± 25^a	95 ± 25^a	99 ± 22^a
	LRS	99 ± 24	133 ± 33^b	106 ± 26	113 ± 35^b	113 ± 33^b	111 ± 31^b	118 ± 30^b	122 ± 29^b
	TS	102 ± 26	146 ± 33^b	109 ± 30	112 ± 27^b	112 ± 29^b	114 ± 33^b	110 ± 33^b	123 ± 38^b
CI (mL/m2)	Control	2.80 ± 0.45	2.97 ± 0.54	2.89 ± 0.38^a	3.23 ± 0.48^a	3.31 ± 0.45^a	3.48 ± 0.33	3.39 ± 0.50^a	3.68 ± 0.42^a
	LRS	2.97 ± 0.52	2.74 ± 0.17	5.38 ± 1.09^b	4.92 ± 1.84^b	4.39 ± 1.17^b	4.10 ± 0.92	4.73 ± 0.86^b	4.77 ± 0.92^b
	TS	3.20 ± 0.40	2.74 ± 0.29	4.57 ± 0.61^c	4.10 ± 0.67^c	3.98 ± 0.63^ab	3.69 ± 0.68	3.78 ± 0.64^a	3.72 ± 0.49^a
SVRI (dynes/sec/cm⁻⁵/m²)	Control	1861 ± 324^a	1789 ± 285^a	1759 ± 228^a	1606 ± 206^a	1556 ± 161^a	1461 ± 130	1479 ± 200^a	1372 ± 176^a
	LRS	1750 ± 271^ab	1990 ± 119^b	891 ± 218^b	1100 ± 318^b	1223 ± 259^b	1294 ± 271	1085 ± 168^b	1113 ± 177^b
	TS	1644 ± 204^b	1996 ± 176^b	1133 ± 149^c	1252 ± 187^b	1314 ± 242^b	1426 ± 178	1351 ± 170^a	1344 ± 158^a
MAP (mmHg)	Control	65 ± 3	66 ± 3	64 ± 4^ab	65 ± 1	65 ± 3	65 ± 3	63 ± 2	63 ± 3
	LRS	65 ± 2	67 ± 1	61 ± 5^a	63 ± 5	65 ± 4	65 ± 2	64 ± 3	65 ± 2
	TS	65 ± 2	67 ± 3	65 ± 4^b	64 ± 3	64 ± 2	64 ± 4	62 ± 3	61 ± 5
CVP (mmHg)	Control	0.3 ± 0.8	0.8 ± 1.5^a	1.0 ± 1.3^a	1.3 ± 1.2	0.7 ± 1.5	1.3 ± 1^a	1.5 ± 1.5^a	0.5 ± 0.8
	LRS	1.2 ± 1.2	−1.2 ± 2.6^b	2.8 ± 2.0^b	0.8 ± 1.3	0.8 ± 1.5	0.8 ± 1.2^a	0.7 ± 2.3^ab	−0.2 ± 1.5
	TS	0.3 ± 0.5	−1.2 ± 1.2^b	1.3 ± 1.2^a	0.8 ± 0.8	−0.3 ± 1.2	−0.8 ± 0.8^b	−0.5 ± 1.2^b	−0.7 ± 1.0
GEDVI (mL/m²)	Control	637 ± 145^a	609 ± 125^a	567 ± 91^a	602 ± 108^a	587 ± 100^a	563 ± 75^a	545 ± 77^a	551 ± 96
	LRS	668 ± 91^a	546 ± 92^b	704 ± 55^b	647 ± 82^ab	617 ± 64^ab	603 ± 52^ab	610 ± 44^b	576 ± 34
	TS	732 ± 164^b	551 ± 121^b	740 ± 187^b	668 ± 128^b	665 ± 177^b	627 ± 126^b	610 ± 139^b	590 ± 128

^{a, b, c}Within each column. For a given time point, treatment group means followed by different superscript letters are significantly different from each other (Tukey′s test, P ≤ 0.05).