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. 2017 May 10;175(8):1305–1317. doi: 10.1111/bph.13817

Figure 7.

Figure 7

Blockade of aldosterone receptors prevents HS‐induced ENaC activity in endothelial cells. (A) Representative ENaC single‐channel current recorded in intact endothelial cells attached to MA in SS rats fed with either NS or HS diet, without (a or c) or with treatment with 10 nM aldosterone (b or d). (B) Summarized P O obtained from the single‐channel recordings as shown in (A). *P < 0.05, significantly different from NS; n = 9. (C) Representative ENaC single‐channel current recorded in intact endothelial cells attached to the artery from SS rats fed with either NS or HS diet without (a or c) or with giving 10 μM eplerenone (EPL; b or d). (D) Summarized P O obtained from the single‐channel recordings as shown in (C). *P < 0.05, significantly different from NS; # P < 0.05, significantly different from HS; n = 9.