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. 2017 Dec 12;11(2):237–243. doi: 10.1111/cts.12530

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© 2017 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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SNO‐Hb, CPB, and transfusion. (a) Circulating RBC SNO‐Hb concentrations in pediatric patients (n = 20; group means are designated by the bars) at various procedural points before, during, and after CPB. SNO‐Hb levels increased after going on bypass and continued to rise into the postoperative period. *Significant difference compared with baseline, P < 0.05, as determined by repeated‐measures ANOVA followed by Dunnet's test. (b) There was no relationship between SNO‐Hb levels and % eBV replaced. (c) The increase in SNO‐Hb correlated inversely with the magnitude of the pre‐to‐posttransfusion increase in Hb (∆Hb) (r = –0.573, P = 0.010). Retention of more blood (i.e., greater increase in postop Hb) was thus associated with lower SNO‐Hb.