Table 3.
Circulating and tissue TSP‐1 levels in healthy (control) versus cardiovascular/CV‐related disease subjects
| CV‐related disease studied | Plasma TSP‐1 (control) (ng/mL) | Plasma TSP‐1 (patient) (ng/mL) | P value of difference | No. of subjects (C; P) | References |
|---|---|---|---|---|---|
| PAD | 218 | 476 | <.0001 | 184; 330 | [ 91 ] |
| PAD | 176 (SEM = 58) | 160 (SEM = 62) | NS | 17; 17 | 92 |
| Pulmonary hypertension | 82 (SD = 16) | 1114 (SD = 136) | <.05 | 19; 93 | [ 101 ] |
| Sickle cell disease | 239 (IQR = 125‐344) | 303 (IQR = 187‐939) | .056 | 17; 27 | 4 |
| Sickle cell disease | 491 (R = 331‐723) | 536 (R = 333‐1107) | NS | 8; 14 | 98 |
| Ischaemic stroke | 146 (SD = 50) | 571 (SD = 226) | <.001 | 150; 192 | [ 102 ] |
| Type I diabetes a | 91 (SEM = 14) | 137 (SEM = 14) | <.05 | 15; 30 | [ 97 ] |
| Vasculitis a | 59 (SD = 29) | 791 (SD = 1412) | .0002 | 33; 20 | [ 96 ] |
| CAD and DM | 518 (SD = 127) | 579 (SD = 106) | <.01 | 108; 103 | [ 94 ] |
| CV‐related disease studied | Interstitial TSP‐1 (control) (ng/mL) | Interstitial TSP‐1 (patient) (ng/mL) | P value of difference | No. of subjects (C; P) | References |
|---|---|---|---|---|---|
| PAD (muscle dialysate) | 54 (SEM = 24) | 219 (SEM = 70) | <.05 | 7; 6 | [ 92 ] |
| Healthy (muscle dialysate) | 100 (SEM = 18) | N/A | N/A | 8; N/A | 132 |
| CV‐related disease studied | Proximal/healthy tissue (AU) | Distal/ischaemic tissue (AU) | P value of difference | No. of subjects (C; P) | References |
|---|---|---|---|---|---|
| Tissue TSP‐1 mRNA in amputated limbs from CLI patients | 2 (SEM = 0.8) | 21 (SEM = 3.9) | .0001 | 13 | [ 93 ] |
Mean/median values are shown in the left of the 2nd and 3rd columns; variations of measurements are shown in the right. Statistical analysis results are shown in the 4th column.
R, range; SEM, standard error of the mean; IQR, interquartile range; SD, standard deviation; N/A, not applicable; NS, non‐significant; DM, diabetes mellitus; CLI, critical limb ischaemia; AU, arbitrary units.
Study did not specify that TSP data are limited to TSP‐1. Values are rounded to the nearest integer (except for values less than 1). Values are for TSP‐1 protein levels unless otherwise noted. Rows with P values smaller than .05 (indicating statistical significance of the difference observed) are bolded.