Table 4.
Circulating and tissue TSP‐1/VEGF protein levels in healthy (control) versus disease subjects
| Disease studied | Plasma TSP‐1 (control, patient) (ng/mL) | Plasma VEGF (control, patient) (pg/mL) | No. of subjects (C; P) | References |
|---|---|---|---|---|
| Cancer (mixed) | 399, 491 NS | 7, 44 P = .003 | 43; 43 | 62 |
| Breast cancer | 396, 419 NS | 53, 54 NS | 65; 37 | 69 |
| Breast cancer (metastatic) | 543, 2255 NS | 12, 29 P = .001 | 16; 17 | 70 |
| Colon cancer | 1698, 328 P < .001 | 2, 48 P < .001 | 36; 33 | 73 |
| Colon cancer | 539, 412 NS | 53, 40 NS | 84; 35 | 74 |
| PAD | 218, 476 P < .0001 | 14, 17 NS | 184; 330 | 91 |
| Disease studied | Serum TSP‐1 (control, patient) (μg/mL) | Serum VEGF (control, patient) (pg/mL) | No. of subjects (C; P) | References |
|---|---|---|---|---|
| NSCLC | 108, 35 P = .012 | 249, 452 P < .001 | 46; 21 | 75 |
| NSCLC | 48, 45 NS | 147, 408 P < .0001 | 60; 60 | 76 |
| NSCLC | 180, 177 NS | 189, 266 NS | 18; 40 | 77 |
| Disease studied | Platelet TSP‐1 (control, patient) (ng/106 platelets) | Platelet VEGF (control, patient) (pg/106 platelets) | No. of subjects (C; P) | References |
|---|---|---|---|---|
| Breast cancer | 27, 29 NS | 0.9, 2 P < .001 | 65; 37 | 69 |
| NSCLC | 9, 15 NS | 22, 41 P = .041 | 68; 68 | 82 |
| Colon cancer | 34, 35 NS | 0.6, 1.3 P < .0001 | 84; 35 | 74 |
| Cancer (mixed) | 38, 29 P = .005 | 0.6, 1.4 P < .0001 | 43; 43 | 62 |
| Disease studied | Tissue TSP‐1 (control/benign, patient/cancer) (μg/g of total protein) | Tissue VEGF (control/benign, patient/cancer) (ng/g of total protein) | No. of subjects (C; P) | References |
|---|---|---|---|---|
| Adrenocortical cancer | 142, 69 P < .01 | 44, 404 P < .001 | (18; 13), (15; 12) | 85 |
| Disease studied | Interstitial TSP‐1 (control, patient) (ng/mL) | Interstitial VEGF (control, patient) (pg/mL) | No. of subjects (C; P) | References |
|---|---|---|---|---|
| PAD | 54, 219 P < .05 | 55, 63 NS | (7; 6), (16; 16) | 92 |
Mean/median values are shown in the left of the 2nd and 3rd columns; statistical analysis results are shown in the right. P values greater than .05 are denoted as NS (non‐significant), and observations with P < .05 are bolded. Values are rounded to the nearest integer (except for values less than 2).