Figure 6.

Schematic of the research and the clinical analysis of the cytoskeleton‐related biomarkers. A, Cell forward movement included several steps. First, the cell formatted protrusions from the non‐adhesion state. Then, the cell adhered to the extra cellular matrix (ECM) and the focal adhesion (FA) established. The FAs grasped the ECM and the tension produced by stress fibres contraction made the FAs dissemble and turnover. Finally, the cell contracted and the cell body was squeezed forward. B, From current study, we can infer that AmotP130 regulated the RhoA translocation from membrane to cytoplasm, inhibiting the Rac1/Cdc42 expression as well as its phosphorylation. Also, from our observation, AmotP130 affected the FAK and the focal adhesion formation. As a result, the cytoskeleton rearrangement and actin polymerization were controlled by AmotP130. C, Comparison of overall survival (OS) and relapse‐free survival (RFS) rates by different level of RhoA and Rac1 mRNA expression in patients with breast cancer from integrated database