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miR‐122 structural and thermodynamic characteristics make it an ideal candidate for AGO2‐mediated silencing. miR‐122 sequence was folded with the mFold RNA tool to assess its stem‐loop structure features and thermodynamic stability. (A) pre‐miR‐122 stem‐loop structure and thermodynamic stability. (B) miR‐122 sequence, relevant segments and nucleotide composition. (C) miR‐122 guide strand stem‐loop structure and thermodynamic stability. “hsa‐” stands for homo sapiens
