Table 3.
miR‐122 targets differentially expressed in adipose, skeletal muscle and pancreas
| Target | Name | Function |
|---|---|---|
| Adipose | ||
| CS | Citrate synthase | TCA cycle; conversion of glucose to acetyl‐CoA |
| IGFBP5 | Insulin‐like growth factor‐binding protein 5 | Regulation of cell growth and metabolism by IGF |
| ACSS2 | Acyl‐CoA synthetase short‐chain family member 2 | Activation of acetate for use in lipid synthesis and energy generation; ethanol oxidation |
| IQGAP1a | IQ motif containing GTPase‐activating protein 1 | Insulin signalling via PKB/Akt pathway; MAPK/ERK signalling cascade |
| ALDOAa | Aldolase, Fructose‐Bisphosphate A | Glycolysis and gluconeogenesis |
| CLIC4a | Chloride intracellular channel 4 | Chloride channel insertion, redox regulated, possibly under oxidizing conditions |
| SUMF2 | Sulfatase‐modifying factor 2 | Sphingolipid metabolism |
| Skeletal muscle | ||
| GYS1a | Glycogen synthase 1 | Glucose metabolism; insulin‐induced glycogenesis |
| NOS1 | Nitric oxide synthase 1 | Nitric oxide synthesis from l‐arginine |
| SOX6a | SRY‐Box 6 | Transcription activator involved in Wnt and ERK signalling |
| ATP1A2a | ATPase Na+/K+ transporting unit alpha 2 | Membrane electrochemical gradient regulation; muscle electrical excitability |
| Pancreas | ||
| CANXa | Calnexin | Ca2+ binding, ER‐associated chaperone; Glycoprotein folding |
| KIF11a | Kinesin Family Member 11 | Kinesin; microtubule‐associated secretory protein transport |
| ATP1A2a | ATPase Na+/K+ transporting unit alpha 2 | Membrane electrochemical regulation; Inhibited in Ca2+ influx and insulin secretion |
| GPX3 | Glutathione peroxidase 3 | Secreted; Antioxidant (H2O2, lipid peroxides, organic hydroperoxides reduction by glutathione) |
Targets that are differentially expressed (per GeneAnalytics LifeMap tool) and involved in IR‐relevant functions are listed.
a
Experimentally verified targets in DIANA‐microT‐CDS (targets verified by microarray, immunoprecipitation or qRT‐PCR).