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. 2018 Jan 29;22(4):2220–2230. doi: 10.1111/jcmm.13502

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© 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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(A) A box–whisker plot showing the relative ITGA4 mRNA expression in histopathologically normal gastric, small intestine and colorectal tissue (green boxes) and in different types of cancer (red boxes). The number of samples studied is indicated in the brackets. (B) Examples of negative, low and high ITGA4 expression in GIST tissue samples (magnification ×200). (C) Association between ITGA4 protein expression at immunohistochemistry and the normalized ITGA4 mRNA expression (P < 0.001) determined from the same samples with qPCR. Panel A is modified from IST Online™ (ist.medisapiens.com).