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. 2018 Feb 9;22(4):2346–2356. doi: 10.1111/jcmm.13526

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© 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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LPS was associated with increased expression of collagen and activation of PSCs. Aniline blue staining showing collagen deposition in the pancreas (blue) of alcohol (ALC, 15 g/kg/d)‐fed rat and ALC rat plus LPS (3 mg/kg once a week for 3 weeks) repeated injections (ALC + LPS) (A); Immunostaining showing the activated PSCs in the pancreas of ALC rat and ALC + LPS rat (B); The area of collagen deposition (C) or the content of Col1A1 (D) or the number of activated PSCs (E) in the pancreas of ALC + LPS rats was significantly more than that of ALC rats. Student's t test, ***P < .001 vs ALC rats (n = 11/group)