Table 1.
Baseline Characteristics
| Groups According to BMI and Metabolic Risk Factors | |||||
|---|---|---|---|---|---|
| MHNW (3048) | MHO (1805) | MUNW (3570) | MUO (9648) | P-value | |
| Clinical Characteristics at Baseline in 18071 adults | |||||
| Age | 35±11 | 38±11 | 40±13 | 44±12 | <0.001 |
| Sex, Female n (%) | 2370 (78%) | 1134 (63%) | 2477 (69%) | 5242 (55%) | <0.001 |
| Race | |||||
| White, n (%) | 2367 (78%) | 1545 (85%) | 2865 (80%) | 8669 (89%) | |
| Black | 36 (1.2%) | 34 (1.9%) | 36 (1%) | 100 (1%) | |
| Asian | 119 (4%) | 27 (1.5%) | 173 (5%) | 133 (1.4%) | |
| Other/Unknown | 525 (17%) | 198 (11%) | 495 (14%) | 746 (8%) | |
| Smoker | 313 (10.3%) | 180 (10%) | 475 (13%) | 1090 (11%) | 0.007 |
| Liver disease | 4 (0.1%) | 15 (1%) | 21 (0.5%) | 127 (1.3%) | 0.001 |
| COPD | 9 (0.3%) | 6 (0.3%) | 11 (0.3) | 38 (0.4%) | 0.81 |
| CKD | 0 (0%) | 1 (0.1%) | 19 (0.5%) | 26 (0.3%) | 0.001 |
| Malignancy | 25 (0.8%) | 32 (1.8%) | 71 (2%) | 221 (2.2%) | 0.001 |
| Characteristics at baseline that define the groups a | |||||
| BMI (kg/m2) | 22.1 ± 1.7 | 28.8 ± 4.1 | 22.6 ± 1.7 | 31.5 ± 5.6 | <0.001 c |
| TG (mmol/l) | 0.93 ± 0.3 | 1.02 ± 0.3 | 1.44 ± 0.9 | 1.98 ± 1.3 | <0.001d |
| HDL-C (mmol/l) | 1.63 ± 0.3 | 1.53 ± 0.3 | 1.45 ± 0.4 | 1.29 ± 0.4 | <0.001d |
| Glucose (mmol/l) | 4.89 ± 0.3 | 5.00 ± 0.3 | 5.17 ± 0.6 | 5.4 ± 0.6 | <0.001d |
| SBP (mmHg) | 115 ± 10 | 118 ± 10 | 126 ± 16 | 131 ± 16 | <0.001d |
| DBP (mmHg) | 71 ± 7.5 | 73 ± 7.1 | 77 ± 10 | 82 ± 10 | <0.001d |
| Hypertension, n (%)b | 0 | 0 | 620 (17.4%) | 2911 (30.2%) | |
| Dyslipidemia, n (%)b | 0 | 0 | 1046 (29.3%) | 4116 (42.7%) | |
MHNW refers to metabolically healthy normal weight, MHO refers to metabolically healthy overweight or obese, MUNW refers to metabolically unhealthy normal weight, MUO refers to metabolically unhealthy overweight or obese.
BMI refers to body mass index, TG refers to triglycerides, HDL-C refers to high density lipoprotein cholesterol, SBP refers to systolic blood pressure, DBP refers to diastolic blood pressure, CKD refers to chronic kidney disease, COPD refers o chronic obstructive pulmonary disease.
Continuous variables expressed as mean ± SD
History of hypertension and dyslipidemia determined based on ICD-9 diagnosis code at baseline
P-value for the comparison between MHNW and MUNW, and between MHO and MUO
P-value for the comparison between MHNW and MHO, and between MUNW and MUO