Table II.

Changes in the Bayley Scales of Infant Development, Third Edition (BSID-III) mean age equivalents after one year of treatment with levodopa or placebo, and the relative difference in the changes between these two groups. A positive “difference in gains” suggests that either the gain (i.e., improvement) in that skill was greater in the levodopa group than the control group, or the reduction (i.e., loss) of that skill was less in the levodopa group compared to the control group.

BSID-III Age equivalent: Mean ± SD	Levodopa (n=29)			Placebo (n=26)			Difference in Gains (Levodopa - Placebo)	Difference in Gains (Generalized Estimating Equation)
	Initial	1-year	Gain in 1 year	Initial	1-year	Gain in 1 year		95% CI	p value
Cognitive scale	19.0 (± 8.0)	19.1 (± 7.2)	0.1	18.3 (± 6.4)	19.1 (± 8.5)	0.8	−0.6	(−2.57, 1.31)	0.52
Receptive Communication*	16.0 (± 8.5)	16.0 (± 9.0)	0.0	15.0 (± 8.2)	16.9 (± 9.0)	1.9	−2.0	(−4.19, 0.535)	0.13
Expressive Communication	9.7 (± 4.0)	9.9 (± 4.0)	0.2	8.7 (± 3.8)	9.1 (± 4.5)	0.4	−0.2	(−1.62, 1.19)	0.76
Fine Motor**	17.8 (± 10.4)	18.1 (± 10.3)	0.4	15.7 (± 7.8)	17.6 (± 8.9)	1.9	−1.6	(−3.57, 1.40)	0.39
Gross Motor***	16.8 (± 6.0)	18.8 (± 8.0)	2.1	15.8 (± 5.0)	17.4 (± 6.5)	1.6	0.5	(−1.59, 1.88)	0.87

^*BSID-III Receptive Communication - Levodopa at 1-year: n=28

^**BSID-III Fine Motor - Levodopa at 1-year: n=28

^***BSID-III Gross Motor - Placebo at 1-year: n=25; Levodopa at Baseline & at 1-year: n=28