TABLE 3.

Odds Ratios for the Association of BMI %Δ Trajectory Group with Prevalent NAFLD in Middle Age in CARDIA

BMI %Δ Group	Unadjusted		Base Model*		Base Model + Y0 BMI		Base Model + Y25 BMI
	N=2615		N=2615		N=2615		N=2611
	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value
Stable	Reference
Moderate Increase	2.65 (1.71–4.09)	0.005	3.35 (2.07–5.43)	0.04	4.40 (2.66–7.31)	0.03	2.56 (1.55–4.21)	0.69
High Increase	4.27 (2.71–6.73)	0.0002	7.80 (4.60–13.23)	<0.0001	11.38 (6.51–19.89)	<0.0001	3.73 (2.13–6.52)	0.001
Extreme Increase	5.51 (3.22–9.42)	<0.0001	12.68 (6.68–24.09)	<0.0001	21.18 (10.75–41.72)	<0.0001	3.68 (1.83–7.41)	0.04

Results presented as Odds Ratio (95% Confidence Interval)

NAFLD = liver attenuation ≤ 40 HU after exclusion for secondary causes of liver fat

^*Base model adjusted for baseline age, sex, race, education, center, cumulative systolic blood pressure (mm Hg-years), number of years with blood pressure medications, cumulative triglycerides (mg/dl-years), cumulative years with diabetes, cumulative alcohol use (drinks/day), physical activity level (exercise units-year) and pack-years of cigarette smoking exposure

Abbreviations: BMI, body mass index; NAFLD, nonalcoholic fatty liver disease; OR, odds ratio; CI, confidence interval