Table 2.

Results of linear mixed effects models using diagnostic group status, age (linear and quadratic term), brain hemisphere (right- or left-side) to predict DTI metrics (fractional anisotropy [FA], mean diffusivity [MD], radial diffusivity [RD], and axial diffusivity [AD]) for the thalamus, posterior limb of the internal capsule (PLIC), and anterior limb of the internal capsule (ALIC). These analyses controlled for head motion and full scale IQ.

		Group		Age		Age2		Hemisphere		Age × Group		Age2 × Group		Hemisphere × Group		Group × Age × Hemisphere
		β	p- value	β	p- value	β	p- value	β	p- value	β	p- value	β	p- value	β	p- value	β	p- value
Thalamus
	FA	−0.0049	<.05	0.0011	<.001	−4.39E-05	.01	0.0043	.009	0.0005	.04	1.67E-05	.36	−1.63E-03	.37	4.25E-05	.86
	MD	0.0014	.66	−0.001	.002	3.99E-05	.08	0.0041	.12	−0.0009	.01	4.29E-05	.09	−9.01E-04	.76	6.72E-05	.86
	RD	0.0037	.31	−0.001	<.001	4.44E-05	.08	−0.0039	.16	−0.0012	.001	2.98E-05	.30	7.56E-04	.81	−1.39E-04	.73
	AD	−0.0017	.65	−0.0002	.53	−4.75E-06	.86	0.0130	<.001	−0.0009	.03	7.38E-05	.01	−3.75E-03	.26	−1.45E-04	.74
PLIC
	FA	−0.0013	.77	0.0010	.002	−6.58E-05	.01	0.0125	<.001	0.0014	<.001	−3.59E-06	.90	3.18E-04	.90	−9.06E-05	.79
	MD	0.0025	.43	−0.0015	<.001	7.05E-05	<.001	−0.0048	.06	−0.0008	.02	1.46E-05	.57	7.73E-04	.79	−3.02E-05	.94
	RD	0.0014	.74	−0.0021	<.001	1.10E-04	<.001	−0.0070	.009	−0.0015	<.001	2.55E-05	.42	1.97E-03	.52	1.08E-04	.78
	AD	0.0030	.61	−0.0009	.03	−3.00E-05	.37	0.0098	.001	−0.0002	.69	3.75E-05	.33	3.20E-04	.92	−6.73E-05	.88
ALIC
	FA	−0.0099	.06	0.0016	<.001	−1.33E-04	<.001	0.0330	<.001	−0.0001	.87	7.18E-05	.06	−2.48E-03	.50	−9.39E-04	<.05
	MD	0.0028	.43	−0.0007	.01	4.30E-05	.06	0.0059	0.01	−0.0008	.02	1.90E-05	.47	−1.93E-03	.46	4.37E-04	.19
	RD	0.0095	<.05	−0.0014	<.001	1.40E-04	<.001	−0.0168	<.001	−0.0009	.06	−3.68E-05	.29	1.35E-03	.69	8.72E-04	<.05
	AD	−0.0040	.56	0.0006	.26	−6.84E-05	.12	0.0552	<.001	−0.0010	.15	8.62E-05	.09	−8.41E-03	.09	−6.55E-04	.30

Bolded effects indicate values that hold after Bonferroni correction.