Table 3.
Multivariate Analysis of Thyroid Cancer Patients with Papillary Carcinoma or Tumors <40mm for Tumor and Patient Characteristics, SEER 18 (2007-2014)
| DISTRIBUTION | MODEL 1: PAPILLARY (vs. Other Histologies) | MODEL 2: TUMOR <40mm (vs. ≥40mm) | |||||
|---|---|---|---|---|---|---|---|
| (N=93,607) | (N=93,607) | (N=89,293) | |||||
|
|
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| N | % | OR* | 95% CI | OR* | 95% CI | ||
| Race | White | 63277 | 68 | 1.00 | Referent | 1.00 | Referent |
| African American | 6389 | 7 | 0.72 | (0.67, 0.78) | 0.51 | (0.47, 0.55) | |
| Asian | 9532 | 10 | 1.40 | (1.29, 1.51) | 0.79 | (0.73, 0.85) | |
| Hispanic | 13878 | 15 | 1.37 | (1.28, 1.47) | 0.64 | (0.60, 0.68) | |
| Native American | 531 | 1 | 1.16 | (0.88, 1.54) | 0.58 | (0.46, 0.75) | |
|
| |||||||
| Year of Diagnosis | 2007 | 9495 | 10 | 1.00 | Referent | 1.00 | Referent |
| 2008 | 10491 | 11 | 1.00 | (0.91, 1.09) | 1.07 | (0.98, 1.17) | |
| 2009 | 11404 | 12 | 0.99 | (0.91, 1.08) | 1.10 | (1.01, 1.21) | |
| 2010 | 11532 | 12 | 1.10 | (1.01, 1.20) | 1.00 | (0.91, 1.09) | |
| 2011 | 12117 | 13 | 1.15 | (1.06, 1.26) | 1.06 | (0.97, 1.16) | |
| 2012 | 12545 | 13 | 1.23 | (1.12, 1.34) | 1.08 | (0.99, 1.18) | |
| 2013 | 12935 | 14 | 1.30 | (1.19, 1.42) | 1.08 | (0.99, 1.18) | |
| 2014 | 13088 | 14 | 1.28 | (1.17, 1.39) | 1.03 | (0.95, 1.13) | |
|
| |||||||
| Age (years) | 15–29 | 8697 | 9 | 2.89 | (2.47, 3.38) | 2.46 | (2.09, 2.90) |
| 30–44 | 24750 | 26 | 2.76 | (2.39, 3.19) | 3.70 | (3.16, 4.33) | |
| 45–54 | 22248 | 24 | 2.85 | (2.49, 3.26) | 4.35 | (3.72, 5.09) | |
| 55–64 | 19088 | 20 | 2.41 | (2.11, 2.76) | 4.20 | (3.59, 4.92) | |
| 65–74 | 12261 | 13 | 1.77 | (1.55, 2.03) | 3.13 | (2.67, 3.67) | |
| 75–84 | 5272 | 6 | 1.46 | (1.27, 1.68) | 1.88 | (1.59, 2.22) | |
| ≥80 | 1291 | 1 | 1.00 | Referent | 1.00 | Referent | |
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| |||||||
| Gender | Male | 22682 | 24 | 1.00 | Referent | 1.00 | Referent |
| Female | 70925 | 76 | 1.05 | (1.00, 1.10) | 2.42 | (2.31, 2.53) | |
|
| |||||||
| Insurance Status | Insured | 80312 | 86 | 1.00 | Referent | 1.00 | Referent |
| Medicaid | 8303 | 9 | 0.86 | (0.80, 0.93) | 0.71 | (0.66, 0.76) | |
| Uninsured | 2474 | 3 | 0.93 | (0.82, 1.06) | 0.55 | (0.49, 0.62) | |
| Unknown | 2518 | 3 | 0.88 | (0.79, 1.00) | 1.01 | (0.86, 1.18) | |
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| |||||||
| Histology at Diagnosis | Papillary | 82445 | 88 | – | – | 1.00 | Referent |
| Follicular | 6707 | 7 | – | – | 0.18 | (0.17, 0.19) | |
| Medullary | 1659 | 2 | – | – | 0.49 | (0.43, 0.56) | |
| Anaplastic | 801 | 1 | – | – | 0.03 | (0.02, 0.04) | |
| Other | 1995 | 2 | – | – | 0.18 | (0.16, 0.21) | |
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| |||||||
| AJCC 6th Ed. Stage at Diagnosis | I | 62314 | 67 | 2.17 | (1.99, 2.36) | – | – |
| II | 7136 | 8 | 0.87 | (0.80, 0.94) | – | – | |
| III | 11680 | 12 | 2.25 | (2.08, 2.44) | – | – | |
| IV | 7830 | 8 | 1.00 | Referent | – | – | |
| Unknown/NA | 4647 | 5 | 1.55 | (1.40, 1.72) | – | – | |
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| |||||||
| Tumor size at Diagnosis (mm) | 0–19 | 56660 | 61 | 11.85 | (10.83, 12.97) | – | – |
| 20–29 | 13932 | 15 | 5.15 | (4.70, 5.64) | – | – | |
| 30–39 | 7782 | 8 | 3.46 | (3.14, 3.81) | – | – | |
| 40–49 | 4610 | 5 | 2.08 | (1.89, 2.29) | – | – | |
| 50–59 | 2639 | 3 | 1.40 | (1.26, 1.57) | – | – | |
| ≥60 | 3670 | 4 | 1.00 | Referent | – | – | |
| Unknown | 4314 | 5 | 1.66 | (1.49, 1.86) | – | – | |
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| |||||||
| Tumor Sequence | First Cancer | 80955 | 86 | – | – | 0.69 | (0.64, 0.74) |
| Second Cancer | 12652 | 14 | – | – | 1.00 | Referent | |
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| |||||||
| Poverty County | <20% | 7519 | 8 | 1.00 | Referent | 1.00 | Referent |
| ≥20% | 86088 | 92 | 1.15 | (1.07, 1.25) | 0.82 | (0.75, 0.90) | |
All bold face ORs are statistically significant using a P < .05
Abbreviations: AJCC, American Joint Committee on Cancer; NA, not available; SEER 18, Surveillance, Epidemiology, and End Results Program 18 database.
A dash (—) indicates a variable that was omitted from each model.
*
All ORs provided were adjusted for other variables in the table.
The sample size was smaller in model 2 because 4314 cases were excluded for unknown tumor sizes.