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. 2018 Jan 30;142(10):2163–2174. doi: 10.1002/ijc.31237

Figure 3.

Figure 3

ENZ and CCX771 combination treatment induces apoptosis in prostate cancer cells. WB of C‐PARP showing increased apoptotic activity by ENZ+CCX771 combination treatment in VCaP (a, c) and C4‐2B cells (b, d). ENZ significantly increased the percentage of sub‐G1 cells compared to the controls in both VCaP and C4‐2B cells (p < 0.05, not indicated in the figure) and AMD3100 significantly increased sub‐G1 cells in VCaP (p < 0.001, not indicated in the figure), but not in C4‐2B cells. Combination treatments showed superior pro‐apoptotic activities compared to single agent ENZ, CCX771 or AMD3100 treatment. The data are represented as the mean ± SE of three experiments performed in triplicate. ### p < 0.001.