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. Author manuscript; available in PMC: 2019 Mar 10.
Published in final edited form as: Ann Neurol. 2018 Mar 10;83(3):522–531. doi: 10.1002/ana.25170

Figure 2. Norepinephrine profiles in neurogenic and non-neurogenic orthostatic hypotension.

Figure 2

A. Plasma norepinephrine levels supine and after 10 minutes of upright tilt in patients with neurogenic vs. non-neurogenic orthostatic hypotension (OH). Note the preserved increase (~ Δ100%) in plasma norepinephrine levels in patients with non-neurogenic OH, indicating intact baroreflex-mediated sympathetic activation. B. Supine plasma norepinephrine levels in central and peripheral autonomic failure compared to non-neurogenic OH. Norepinephrine levels were lowest in patients with peripheral lesions (i.e., Parkinson disease, dementia with Lewy bodies, and pure autonomic failure), indicating severe involvement of post-ganglionic sympathetic neurons in this group. Differences assessed with ANOVA.