Skip to main content
. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Dev Neurobiol. 2018 Feb 6;78(4):391–402. doi: 10.1002/dneu.22579

Figure 2.

Figure 2

Mechanisms of folate action in the developing and mature nervous system. Folate is taken into neural cells through folate receptor 1 (FOLR1) or reduced folate carrier (RFC) to be used in DNA and RNA biosynthesis, DNA repair and one-carbon metabolic reactions. These roles of folate as a vitamin are needed for neural cell division during periods of rapid growth and neural tissue repair. Alternatively, folate interacts with its receptor, triggering specific signaling mechanisms that enable the shaping of the neural plate during neural tube formation and modulation of synaptic activity to facilitate neural function.