Figure 6. Electrospun nanofibers for regulating cell behavior.

(A) Schematic and image of ‘tumor guide’ device inserted into a rat brain, three-dimensional view (left), ‘tumor guide’ device view (middle) of the brain and device, and digital image of extracted brain containing a conduit from the top view (right). (B) Fluorescence images of the tumor cells at day 0 and day 10 on the aligned nanofiber films. The cells migrated further on the aligned nanofiber film. (C) The glioblastoma cells were effectively introduced to apoptosis by cyclopamine released from collagen hydrogel after they were ‘fishing’ out. Reproduced with permission.^[23] Copyright 2014, Nature Publishing Group.