Table 1.
Representative anticancer drug, gene, and virus encapsulation into electrospun nanofibers with varied polymer compositions.
| Drug | Carrier | Loading method |
Type of cancer | Refs |
|---|---|---|---|---|
| CPT11, SN-38 | PCL/PGC-C18 | Encapsulation | Colorectal cancer | [27] |
| Cisplatin | PEO/PLA; PCL/PGC-C18 | Encapsulation | Cervical cancer; lung cancer | [28] |
| Doxorubicin | Chitosan/PLA; PLGA/HAp; PLA/mesoporous silica nanoparticles; poly(NIPAAm-co-HMAAm); silica nanoparticles-DOX-CaCO3/PLLA; polydopamine/PCL; gelatin/PCL-PEG micelle; | Encapsulation Immobilization | Graffi myeloid tumor; epithelial carcinoma; orthotopic secondary hepatic carcinoma; postsurgical cancer; skin cancer; HeLa cells; H1299 cells; breast cancer | [29] |
| Doxorubicin and camptothecin | PLGA/gelatin/ZnO nanospheres | Encapsulation | Liver cancer | [30] |
| Paclitaxel | PLGA; Chitosan/PEO | Encapsulation | Glioma; prostate cancer | [31] |
| Paclitaxel and doxorubicin | PEG-PLA | Encapsulation | Glioma | [32] |
| 5-aminolevulinic acid | PVA | Encapsulation | Cholangiocarcinoma | [33] |
| Hydroxycamptothecin | PEG-PDLA | Encapsulation | Hepatoma | [34] |
| Combretastatin A-4 and hydroxycamptothecin | PEG-PLA | Encapsulation | Breast cancer | [35] |
| Titanocene dichloride | PLLA | Encapsulation | Lung cancer | [36] |
| Temozolomide | PLGA/PLA/PCL | Encapsulation | Glioma | [15] |
| 1,3-bis(2-chloroethyl)-1-nitrosourea | PEG-PLLA | Encapsulation | Glioma | [37] |
| Green tea polyphenols | PCL/MWCNTs | Encapsulation | Lung cancer and liver cancer | [38] |
| Curcumin | PCL-PEG-PCL; PLGA | Encapsulation | Glioma; skin | [39] |
| Daunorubicin | Poly(N-isopropylacrylamide)-co-polystyrene; | Encapsulation | Leukemia | [40] |
| Daunorubicin and Fe3O4nanoparticles | PLA | Encapsulation | Leukemia | [41] |
| Cdk2 siRNA | plasmid DNA/PCL | Encapsulation | Breast cancer | [42] |
| MMP-2 RNAi and Paclitaxel | PEI/DNA nanoparticles/PLGA | Encapsulation | brain tumor | [43] |
| Inactivated sendai virus | PCL | Surface immobilization | Prostate cancer | [44] |
| Fe3O4 nanoparticles | Chitosan | Surface immobilization | Colon adenocarcinoma | [45] |