Figure 8.

Paroxon treatment induces intestinal goblet cells (GC) degranulation. Ileum sections from (A) saline- or (B) paraoxon-pretreated mice were stained with hematoxylin and eosin. GC (black arrows) can be seen between the columnar absorbing cells. The cytoplasm of Paneth cells (white arrows) at the bottom of the intestinal crypts is full of acidophylic granules. Images were taken at 400× magnification. L, intestinal lumen; MM, muscularis mucosa. (C,D) Transmission electron micrographs of ileal epithelium from saline- or paraoxon-pretreated mice. (C) GC (arrowhead) in saline-treated animals presented with a distended apical part that contains large rounded mucous globules of moderate electron density. (D) In contrast, GC from paraoxon-treated mice showed either an active degranulation of their granules to the intestinal lumen (L) or completely degranulated cells. Original magnification of the micrographs 4,200×.