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. 2018 Mar 19;10:66. doi: 10.3389/fnagi.2018.00066

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Copyright © 2018 Wang, Huang, Zhao, Zhao and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Catalpol activated the extracellular signal-related kinase/cAMP-response element binding protein (ERK/CREB) signal pathway in SweAPP N2a cells. (A,B) SweAPP N2a cells were treated with catalpol at 200 μM or 400 μM for 1 h. (A) Immunoblotting analyses and (B) quantifications showed that the phosphorylation levels of ERK was markedly increased after treatments with catalpol. (C) Immunoblotting analyses and (D) quantifications showed that catalpol significantly increased the phosphorylation levels of the transcription factor CREB, which is the downstream of ERK. The data are expressed as the mean ± SEM. n = 3. The p values were calculated using one-way ANOVA.