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. 2018 Mar 19;10:66. doi: 10.3389/fnagi.2018.00066

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Copyright © 2018 Wang, Huang, Zhao, Zhao and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Catalpol promoted sAPPα expression through ERK/CREB signaling pathway. SweAPP N2a cells were pre-treated with the ERK inhibitor U0126 for 2 h, and then treated with 200 μM catalpol for 18 h. (A) Immunoblot images and (B) quantifications show that the expression levels of sAPPα were assessed by western blot. (C,D) The expression levels of p-CREB were markedly decreased in cells treated with both U0126 and catalpol, compared with catalpol-treated cells (C, representative pictures; D, quantification), compare to these from catalpol-treated cells. The data are expressed as the mean ± SEM. n = 3. The p values were calculated using one-way ANOVA.