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. 2018 Mar 19;9:559. doi: 10.3389/fimmu.2018.00559

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Copyright © 2018 Chen, Wang, Li, Yu, Chen and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Binding of factor H (FH) to neutrophils do not activate CR3 (CD11b/CD18). Activate CR3 on neutrophils were detected using phycoerythrin-conjugated anti-CD11b monoclonal antibodies CBRM1/5 after incubation with FH, TNF-α, or fMLP. Unstimulated cells incubated with medium were set as blank controls. (A,B) Representative histograms showing that priming neutrophils with TNF-α or fMLP-induced expression of activate CR3, while FH did not activate CR3. (C) Analysis of expression of activate CR3. The expression level of active CR3 on nuetrophils after incubation with FH was comparable to unstimulated neutrophils. The values represent mean ± SD derived from three independent experiments.