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. 2018 Mar 19;9:188. doi: 10.3389/fphys.2018.00188

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Copyright © 2018 Morales-Alamo, Guerra, Santana, Martin-Rincon, Gelabert-Rebato, Dorado and Calbet.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulation of pyruvate dehydrogenase (PDH) activity in skeletal muscle. Pyruvate dehydrogenase complex (PDC) is regulated by phosphorylation and dephosphorylation by pyruvate dehydrogenase kinase (PDK) and pyruvate dehydrogenase phosphatase (PDP), respectively. PDC catalyzes the irreversible decarboxylation of pyruvate to Acetyl-CoA, which can be oxidized through the tricarboxylic acid cycle (TCA). DLAT, dihydrolipoamide S-acetyltransferase; DLD, dihydrolipoamide dehydrogenase; ATP, adenosine triphosphate; ADP, adenosine diphosphate; NAD, nicotinamide adenine dinucleotide; NADH, nicotinamide adenine dinucleotide reduced; CoASH, coenzyme A.