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. 2017 Nov 8;119(2):641–651. doi: 10.1152/jn.00092.2017

Fig. 5.

Fig. 5.

Noxious electrical stimulation applied to the skin (sensitizing stimuli) elicits potentiation of the P-cell synapse and P-elicited shortening that is 2-AG/TRPV dependent. A: sample recording of P-cell action potential (i; scale bar: 20.0 mV, 50 ms) and the EPSPs elicited before and after application of sensitizing stimuli (Sens) (ii; scale bar: 2 mV, 50 ms) or Sens + SB (iii; scale bar same as ii) and sample recording of the train of P-cell action potentials used to elicit shortening (iv; scale bar: 20.0 mV, 50 ms) and the shortening responses following Sens (v and vi; scale bar: 2 mV, 50 ms) or Sens + SB (vii and viii; scale bar: 2.0 mV, 50 ms). Black and gray traces are pre- and posttest recordings, respectively. B: average ± SE changes in EPSP amplitude (left) and magnitude of the shortening response (right) in the no sensitization control (No stim), sensitized (Sens), THL with no stimulation (THL), THL + Sens, SB with no stimulation (SB), SB + Sens, ritanserin with no stimulation (RIT), and RIT + Sens groups. *Statistically significant difference compared with controls based on a 1-way ANOVA with Student-Newman-Keuls post hoc test (see results). n = 5 for all treatment and control groups.