Figure 2.
Efficacy endpoints, by visit (modified intent-to-treat population). (A) SRI4 response; (B) SELENA-SLEDAI ≥4 point reduction; (C) SRI7 response and (D) time to first severe flare. *P<0.05 (logistic regression model for belimumab vs placebo with independent variables treatment group, country, baseline SELENA-SLEDAI score (≤9 vs ≥10) and baseline complement levels (low C3 and/or C4 vs no low C3 or C4)). C3/C4, complement 3/complement 4; SELENA-SLEDAI, Safety of Oestrogen in Lupus Erythematosus National Assessment-SLE Disease Activity Index; SFI, SLE Flare Index; SRI, SLE Responder Index.