Table 1.

Reactome pathway analysis

Pathway	Adj. P value
Group A vs non-OA
EukAryotic translation elongation	6.2e–63
Extracellular matrix organisation	7.3e–13
Chemokine receptors bind chemokines	0.00615
MyD88 deficiency (TLR2/4)	0.04693
Glycosaminoglycan metabolism	0.00584
Inflammasomes	0.01242
Group B vs non-OA
Eukaryotic translation elongation	1.6e–69
Extracellular matrix organisation	4.3e–12
Negative regulation of TCF-dependent signalling by WNT ligand antagonists	0.00707
Regulation of complement cascade	0.00758
Eicosanoid ligand-binding receptors	0.00758
Syndecan interactions	0.01795
Group B vs Group A
Extracellular matrix organisation	9.2e–11
Chemokine receptors bind chemokines	8.9e–08
Complement cascade	0.00012
G alpha (i) signalling events	0.00036
Adaptive immune system	0.00068

A selection of highly significant differentially regulated Reactome pathways between OA Group A (n=32) and Group B (n=26) and non-OA (n=10).

OA, osteoarthritis.