Table 2.

Expression changes in circadian clock related genes in  patient Groups A and B; 2B—expression changes in mechanosensitive ion channels and cytoskeletal proteins in patient Groups A and B

	Name	Group A fold change	Group B fold change
(A) Gene
ARNTL	Bmal1 primary clock oscillator	−1.67	−1.88
NPAS2	Transcription factor activator interacts with Bmal1	−1.64	−1.85
CRY1	Inhibitor of Bmal1/NPAS2 as part of clock oscillator	+1.33	+1.37
PER1	Inhibitor of the core clock oscillator	−1.50	−1.87
NR1D1	Rev-Erbα nuclear hormone receptor, negative regulator of Bmal1 transcription	−1.72	−1.90
BHLHE40	DEC1, Basic helix-loop-helix Target of clock	NS	−1.35
RORC	Nuclear hormone receptor transcr. factor, positive regulator of Bmal1 transcription	−1.40	−2.15
DBP	Transcription factor activating clock target genes via D-box cis elements	+2.39	+1.95
NFIL3	Transcription factor suppressing clock target genes via D-box cis elements	−2.29	−2.67
NFATC1	Component of DNA binding transcription complex	+1.49	+1.30
NFATC2	Component of DNA binding transcription complex	+3.02	+3.33
(B) Ion channels
TRPV4	Mechanosensitive Ca++channel	+2.28	+1.59
AQP1	Aquaporin, water channel	NS	+3.28
ANO1	Voltage gated Ca++activated Cl- channel	+2.27	+3.15
KCNA1	K+voltage gated channel	+1.61	+1.63
KCNQ5	K+voltage gated channel	+1.53	+1.57
KCNS3	K+voltage gated channel modifier	NS	+2.53
KCNK6	K+channel	NS	+1.31
KCNN3	Ca++activated K+channel	+1.71	+2.64
KCNN4	Ca++activated K+channel	NS	+2.86
KCNMB4	Ca++activated K+channel subunit 4	NS	+1.58
KCTD12	K+channel tetramerisation domain containing 12	NS	+1.96
SCNNIA	Non-gated Na+channel	−3.46	−4.94
Cytoskeleton
ACTA2	Alpha smooth muscle actin	−2.86	+1.81
VIN	Vinculin cytoskeletal protein	NS	+1.37
TMSB4X	Thymosin B4 cytoskeletal protein	NS	+1.87
EZR	Ezrin-Plasma mem-cytoskeletal link	NS	+2.08
TPM4	Tropomyosin 4 actin binding	NS	+1.36
MYH9/11	Smooth muscle myosin heavy chain, contractile protein	9—NS 11—NS	+1.32 +2.30

GWAS, genome-wide association study.