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. 2017 Nov 8;52(6):359–367. doi: 10.1136/bjsports-2017-098161

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Expression of inflammatory genes in diseased Achilles tendons. Tendinopathic (n=11 donors) and ruptured Achilles (n=13 donors) tissue samples showed a complex inflammation gene signature encompassing activation of NF-κB (IL-8, PTGS2), interferon (IRF1, IRF5 and CXCL10), STAT-6 (CD206) and glucocorticoid receptor activation pathways (CD163). The inflammation signature of diseased Achilles tendons was compared with healthy hamstring tendons (n=6 donors). Gene expression is shown normalised to β-actin; bars represent median values. mRNA, messenger RNA.