Table I.

Details of diagnostic modules and functional pathways in post-menopausal osteoporosis.

Module no.	Seed gene	z-score	Number of genes	Enriched pathway	Adjusted P-value of the pathway
1	AK6	69.94	15	Histone acetylation by HATs	6.86×10−4
2	PSMC5	58.07	16	Ubiquitin-dependent degradation of cyclin D	6.55×10−6
3	TAF12	49.20	15	Ubiquitin-dependent degradation of cyclin D	2.21×10−9
4	SF3B4	38.79	15	Degradation of β-catenin by the destruction complex	5.96×10−6
5	U2AF2	49.03	16	mRNA splicing	9.96×10−10
6	CLP1	48.49	15	Processing of capped intron-containing Pre-mRNA	3.38×10−9
7	PSMA5	43.00	15	Histone acetylation by HATs	3.39×10−5
8	NDUFAF1	40.49	15	Processing of capped intron-containing pre-mRNA	3.38×10−9
9	YBX1	40.19	15	mRNA Splicing	9.96×10−10

AK6, adenylate kinase 6; PSMC5, proteasome 26S subunit ATPase 5; TAF12, TATA box-binding protein-associated factor 12; SF3B4, splicing factor 3B subunit 4; U2AF2, U2 small nuclear ribonucleoprotein auxiliary factor; CLP1, cleavage and polyadenylation factor I subunit 1; PSMA5, proteasome subunit α5; NDUFAF1, NADH-ubiquinone oxidoreductase (complex I); YBX1, Y box binding protein 1; HATs, histone acetyltransferases.